Table 1 Demographic data and clinical results of the 22 patients with a history of penicillin allergy and with initial positive serum specific IgE to penicillin
Patient data* | Primary reaction | Initial IgE | Iv/single dose challenge | Post IgE (4 w after challenge) | Challenge p.o.7 | Post IgE (4 w after challenge) | ||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Age (years) | ||||||||||||||||||||||||||||
No | Sex | IgE pos | IgE neg | Culprit drug | Type of reaction | Total | Pen V | Pen G | AMP | AX | MDM | Pen G | Pen V | AMP | AX | DX | Pen V | Pen G | AMP | AX | Pen V | AMP | AX | DX | Pen V | Pen G | AMP | AX |
1 | F | 34 | 35 | Penicillin V | urt (IR) | 53.1 | 0.9 | 0 | 0 | 0 | 0 | Neg | Pos | NT | NT | NT | 2.8 | 0 | 0 | 0 | \ | NT | NT | NT | NT | NT | NT | NT |
2 | M | 65 | 69 | Penicillin V | urt (NIR) | 248.6 | 0.4 | 0 | 0 | 0 | 0 | Neg | Pos | NT | NT | NT | 0 | 0 | 0 | 0 | \ | NT | NT | NT | NT | NT | NT | NT |
3 | M | 38 | 38 | Penicillin V | urt+angio (NIR) | 101.5 | 0.5 | 0 | 0 | 0 | 0 | Neg | Neg | NT | NT | NT | 0 | 0 | 0 | 0 | Pos | NT | NT | NT | 0.4 | 0 | 0 | 0 |
4 | M | 18 | 19 | Penicillin V | urt (NIR) | 54.1 | 0.4 | 0 | 0 | 0 | 0 | Neg | Neg | NT | NT | NT | 0 | 0 | 0 | 0 | Pos | NT | NT | NT | 0 | 0 | 0 | 0 |
5 | M | 56 | 57 | Dicloxacillin | urt+angio (IR) | 271.7 | 0.5 | 0.4 | 0.8 | 0 | 0 | NT | NT | NT | NT | Pos | 0.4 | 0 | 0.4 | 0 | \ | NT | NT | NT | NT | NT | NT | NT |
6 | M | 77 | 81 | Dicloxacillin | rash (NIR) | 1773.0 | 0 | 0 | 0.7 | 0 | 0 | Neg | Neg | NT | NT | Neg | 0 | 0 | 0 | 0 | Neg | NT | NT | Pos | 0 | 0 | 0 | 0 |
7 | F | 30 | 34 | Penicillin V | urt (IR) | 4.2 | 0.9 | 0.8 | 0 | 0 | 0 | Neg | Neg | NT | NT | NT | 1.2 | 0.5 | 0 | 0 | \ | NT | NT | NT | NT | NT | NT | NT |
8 | M | 30 | 33 | Penicillin V | urt (IR) | 26.8 | 0.4 | 0 | 0 | 0 | 0 | Neg | Neg | NT | NT | NT | 0.8 | 0 | 0 | 0 | \ | NT | NT | NT | NT | NT | NT | NT |
9 | M | 51 | 56 | Penicillin V | rash (NIR) | 580.7 | 0 | 0 | 0.4 | 0 | 0 | Neg | Neg | NT | NT | NT | 0.5 | 0.7 | 0 | 0 | \ | NT | NT | NT | NT | NT | NT | NT |
10 | M | 43 | 43 | Penicillin V | rash (IR) | 10.2 | 0.4 | 0 | 0 | 0 | 0 | Neg | Neg | NT | NT | NT | 0 | 0 | 0 | 0 | Neg | NT | NT | NT | >100 | 0 | 0 | 0 |
11 | M | 58 | 58 | Penicillin V | urt (IR) | 142.7 | 0.4 | 0 | 0 | 0 | 0 | Neg | Neg | NT | NT | NT | 0 | 0 | 0 | 0 | Neg | NT | NT | NT | 1.5 | 0.4 | 0 | 0 |
12 | F | 48 | 49 | Penicillin V | urt+angio (IR) | 38.3 | 0.8 | 0 | 0 | 0 | 2.3 | Neg | Neg | NT | NT | NT | 0 | 0 | 0 | 0 | Neg | NT | NT | NT | 3.9 | 0 | 0 | 0 |
13 | M | 51 | 55 | Penicillin V | rash (NIR) | 363.7 | 0.4 | 0 | 0 | 0 | 0 | Neg | Neg | NT | NT | NT | NT | NT | NT | NT | Neg | NT | NT | NT | 4.3 | 0.4 | 0.4 | 0 |
14 | F | 46 | 49 | Penicillin V | urt+angio (NIR) | 4.3 | 3.4 | 1.4 | 0.5 | 0 | 0 | Neg | Neg | NT | NT | NT | 0 | 0 | 0 | 0 | Neg | NT | NT | NT | 9.8 | 2.8 | 2.9 | 1.3 |
15 | F | 34 | 38 | Penicillin V | rash (NIR) | 491.2 | 0 | 0 | 0.9 | 0 | 0 | Neg | Neg | Neg | NT | NT | 0 | 0 | 0 | 0 | Neg | Neg | NT | NT | 0 | 0 | 0 | 0 |
16 | F | 63 | 67 | Amoxicillin | rash (NIR) | 107.3 | 0.4 | 0 | 0 | 0 | 0 | Neg | Neg | NT | Neg | NT | 0 | 0 | 0 | 0 | Neg | NT | Neg | NT | 0 | 0 | 0 | 0 |
17 | M | 60 | 61 | Amoxicillin | rash (NIR) | 698.1 | 3.2 | 0 | 0 | 0 | 0 | Neg | Neg | NT | NT | NT | 0 | 0 | 0 | 0 | Neg | NT | Neg | NT | 0 | 0 | 0 | 0 |
18 | F | 60 | 67 | Amoxicillin | urt (NIR) | NT | 0.5 | 0 | 0 | 0 | 0 | Neg | Neg | NT | Neg | NT | 0 | 0 | 0 | 0 | NT | NT | Neg | NT | 0 | 0 | 0 | 0 |
19 | M | 52 | 52 | Penicillin V | rash (NIR) | NT | 0 | 0 | 0.7 | 0 | 0 | Neg | Neg | Neg | NT | NT | NT | NT | NT | NT | Neg | Neg | NT | NT | NT | NT | NT | NT |
20 | F | 56 | 61 | Amoxicillin | rash (NIR) | NT | 1.1 | 1.0 | 0 | 0 | 0 | Neg | Neg | NT | Neg | NT | NT | NT | NT | NT | Neg | NT | Neg | NT | NT | NT | NT | NT |
21 | F | 58 | 59 | Amoxicillin | rash (NIR) | NT | 0.4 | 0 | 0 | 0 | 0 | Neg | Neg | NT | Neg | NT | NT | NT | NT | NT | Neg | NT | Neg | NT | NT | NT | NT | NT |
22 | F | 35 | 43 | Penicillin V | urt (NIR) | 355.8 | 0.4 | 0 | 0 | 0 | 0 | Neg | Neg | NT | NT | NT | NT | NT | NT | NT | Neg | NT | NT | NT | NT | NT | NT | NT |