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Table 1 Demographic data and clinical results of the 22 patients with a history of penicillin allergy and with initial positive serum specific IgE to penicillin

From: Positive serum specific IgE has a short half-life in patients with penicillin allergy and reversal does not always indicate tolerance

Patient data* Primary reaction Initial IgE Iv/single dose challenge Post IgE (4 w after challenge) Challenge p.o.7 Post IgE (4 w after challenge)
   Age (years)
No Sex IgE pos IgE neg Culprit drug Type of reaction Total Pen V Pen G AMP AX MDM Pen G Pen V AMP AX DX Pen V Pen G AMP AX Pen V AMP AX DX Pen V Pen G AMP AX
1 F 34 35 Penicillin V urt (IR) 53.1 0.9 0 0 0 0 Neg Pos NT NT NT 2.8 0 0 0 \ NT NT NT NT NT NT NT
2 M 65 69 Penicillin V urt (NIR) 248.6 0.4 0 0 0 0 Neg Pos NT NT NT 0 0 0 0 \ NT NT NT NT NT NT NT
3 M 38 38 Penicillin V urt+angio (NIR) 101.5 0.5 0 0 0 0 Neg Neg NT NT NT 0 0 0 0 Pos NT NT NT 0.4 0 0 0
4 M 18 19 Penicillin V urt (NIR) 54.1 0.4 0 0 0 0 Neg Neg NT NT NT 0 0 0 0 Pos NT NT NT 0 0 0 0
5 M 56 57 Dicloxacillin urt+angio (IR) 271.7 0.5 0.4 0.8 0 0 NT NT NT NT Pos 0.4 0 0.4 0 \ NT NT NT NT NT NT NT
6 M 77 81 Dicloxacillin rash (NIR) 1773.0 0 0 0.7 0 0 Neg Neg NT NT Neg 0 0 0 0 Neg NT NT Pos 0 0 0 0
7 F 30 34 Penicillin V urt (IR) 4.2 0.9 0.8 0 0 0 Neg Neg NT NT NT 1.2 0.5 0 0 \ NT NT NT NT NT NT NT
8 M 30 33 Penicillin V urt (IR) 26.8 0.4 0 0 0 0 Neg Neg NT NT NT 0.8 0 0 0 \ NT NT NT NT NT NT NT
9 M 51 56 Penicillin V rash (NIR) 580.7 0 0 0.4 0 0 Neg Neg NT NT NT 0.5 0.7 0 0 \ NT NT NT NT NT NT NT
10 M 43 43 Penicillin V rash (IR) 10.2 0.4 0 0 0 0 Neg Neg NT NT NT 0 0 0 0 Neg NT NT NT >100 0 0 0
11 M 58 58 Penicillin V urt (IR) 142.7 0.4 0 0 0 0 Neg Neg NT NT NT 0 0 0 0 Neg NT NT NT 1.5 0.4 0 0
12 F 48 49 Penicillin V urt+angio (IR) 38.3 0.8 0 0 0 2.3 Neg Neg NT NT NT 0 0 0 0 Neg NT NT NT 3.9 0 0 0
13 M 51 55 Penicillin V rash (NIR) 363.7 0.4 0 0 0 0 Neg Neg NT NT NT NT NT NT NT Neg NT NT NT 4.3 0.4 0.4 0
14 F 46 49 Penicillin V urt+angio (NIR) 4.3 3.4 1.4 0.5 0 0 Neg Neg NT NT NT 0 0 0 0 Neg NT NT NT 9.8 2.8 2.9 1.3
15 F 34 38 Penicillin V rash (NIR) 491.2 0 0 0.9 0 0 Neg Neg Neg NT NT 0 0 0 0 Neg Neg NT NT 0 0 0 0
16 F 63 67 Amoxicillin rash (NIR) 107.3 0.4 0 0 0 0 Neg Neg NT Neg NT 0 0 0 0 Neg NT Neg NT 0 0 0 0
17 M 60 61 Amoxicillin rash (NIR) 698.1 3.2 0 0 0 0 Neg Neg NT NT NT 0 0 0 0 Neg NT Neg NT 0 0 0 0
18 F 60 67 Amoxicillin urt (NIR) NT 0.5 0 0 0 0 Neg Neg NT Neg NT 0 0 0 0 NT NT Neg NT 0 0 0 0
19 M 52 52 Penicillin V rash (NIR) NT 0 0 0.7 0 0 Neg Neg Neg NT NT NT NT NT NT Neg Neg NT NT NT NT NT NT
20 F 56 61 Amoxicillin rash (NIR) NT 1.1 1.0 0 0 0 Neg Neg NT Neg NT NT NT NT NT Neg NT Neg NT NT NT NT NT
21 F 58 59 Amoxicillin rash (NIR) NT 0.4 0 0 0 0 Neg Neg NT Neg NT NT NT NT NT Neg NT Neg NT NT NT NT NT
22 F 35 43 Penicillin V urt (NIR) 355.8 0.4 0 0 0 0 Neg Neg NT NT NT NT NT NT NT Neg NT NT NT NT NT NT NT
  1. *Patient data are illustrating the patients’ age at the time of respective IgE positive and IgE negative results.
  2. F: female, M: male, urt: urticarial, angio: angioedema, p.o.7: 7-day oral challenge, pos: positive challenge, neg: negative challenge, NT: not tested, MDM: Minor determinant mix for penicillin, \: not tested due to either positive i.v./single dose challenge or to positive post-challenge specific IgE to penicillin, bold data: positive result, 0: negative result.
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Clinical and Translational Allergy

ISSN: 2045-7022

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