Patient data*
|
Primary reaction
|
Initial IgE
|
Iv/single dose challenge
|
Post IgE (4 w after challenge)
|
Challenge p.o.7
|
Post IgE (4 w after challenge)
|
---|
| |
Age (years)
|
---|
No
|
Sex
|
IgE pos
|
IgE neg
|
Culprit drug
|
Type of reaction
|
Total
|
Pen V
|
Pen G
|
AMP
|
AX
|
MDM
|
Pen G
|
Pen V
|
AMP
|
AX
|
DX
|
Pen V
|
Pen G
|
AMP
|
AX
|
Pen V
|
AMP
|
AX
|
DX
|
Pen V
|
Pen G
|
AMP
|
AX
|
---|
1
|
F
|
34
|
35
|
Penicillin V
|
urt (IR)
|
53.1
|
0.9
|
0
|
0
|
0
|
0
|
Neg
|
Pos
|
NT
|
NT
|
NT
|
2.8
|
0
|
0
|
0
|
\
|
NT
|
NT
|
NT
|
NT
|
NT
|
NT
|
NT
|
2
|
M
|
65
|
69
|
Penicillin V
|
urt (NIR)
|
248.6
|
0.4
|
0
|
0
|
0
|
0
|
Neg
|
Pos
|
NT
|
NT
|
NT
|
0
|
0
|
0
|
0
|
\
|
NT
|
NT
|
NT
|
NT
|
NT
|
NT
|
NT
|
3
|
M
|
38
|
38
|
Penicillin V
|
urt+angio (NIR)
|
101.5
|
0.5
|
0
|
0
|
0
|
0
|
Neg
|
Neg
|
NT
|
NT
|
NT
|
0
|
0
|
0
|
0
|
Pos
|
NT
|
NT
|
NT
|
0.4
|
0
|
0
|
0
|
4
|
M
|
18
|
19
|
Penicillin V
|
urt (NIR)
|
54.1
|
0.4
|
0
|
0
|
0
|
0
|
Neg
|
Neg
|
NT
|
NT
|
NT
|
0
|
0
|
0
|
0
|
Pos
|
NT
|
NT
|
NT
|
0
|
0
|
0
|
0
|
5
|
M
|
56
|
57
|
Dicloxacillin
|
urt+angio (IR)
|
271.7
|
0.5
|
0.4
|
0.8
|
0
|
0
|
NT
|
NT
|
NT
|
NT
|
Pos
|
0.4
|
0
|
0.4
|
0
|
\
|
NT
|
NT
|
NT
|
NT
|
NT
|
NT
|
NT
|
6
|
M
|
77
|
81
|
Dicloxacillin
|
rash (NIR)
|
1773.0
|
0
|
0
|
0.7
|
0
|
0
|
Neg
|
Neg
|
NT
|
NT
|
Neg
|
0
|
0
|
0
|
0
|
Neg
|
NT
|
NT
|
Pos
|
0
|
0
|
0
|
0
|
7
|
F
|
30
|
34
|
Penicillin V
|
urt (IR)
|
4.2
|
0.9
|
0.8
|
0
|
0
|
0
|
Neg
|
Neg
|
NT
|
NT
|
NT
|
1.2
|
0.5
|
0
|
0
|
\
|
NT
|
NT
|
NT
|
NT
|
NT
|
NT
|
NT
|
8
|
M
|
30
|
33
|
Penicillin V
|
urt (IR)
|
26.8
|
0.4
|
0
|
0
|
0
|
0
|
Neg
|
Neg
|
NT
|
NT
|
NT
|
0.8
|
0
|
0
|
0
|
\
|
NT
|
NT
|
NT
|
NT
|
NT
|
NT
|
NT
|
9
|
M
|
51
|
56
|
Penicillin V
|
rash (NIR)
|
580.7
|
0
|
0
|
0.4
|
0
|
0
|
Neg
|
Neg
|
NT
|
NT
|
NT
|
0.5
|
0.7
|
0
|
0
|
\
|
NT
|
NT
|
NT
|
NT
|
NT
|
NT
|
NT
|
10
|
M
|
43
|
43
|
Penicillin V
|
rash (IR)
|
10.2
|
0.4
|
0
|
0
|
0
|
0
|
Neg
|
Neg
|
NT
|
NT
|
NT
|
0
|
0
|
0
|
0
|
Neg
|
NT
|
NT
|
NT
|
>100
|
0
|
0
|
0
|
11
|
M
|
58
|
58
|
Penicillin V
|
urt (IR)
|
142.7
|
0.4
|
0
|
0
|
0
|
0
|
Neg
|
Neg
|
NT
|
NT
|
NT
|
0
|
0
|
0
|
0
|
Neg
|
NT
|
NT
|
NT
|
1.5
|
0.4
|
0
|
0
|
12
|
F
|
48
|
49
|
Penicillin V
|
urt+angio (IR)
|
38.3
|
0.8
|
0
|
0
|
0
|
2.3
|
Neg
|
Neg
|
NT
|
NT
|
NT
|
0
|
0
|
0
|
0
|
Neg
|
NT
|
NT
|
NT
|
3.9
|
0
|
0
|
0
|
13
|
M
|
51
|
55
|
Penicillin V
|
rash (NIR)
|
363.7
|
0.4
|
0
|
0
|
0
|
0
|
Neg
|
Neg
|
NT
|
NT
|
NT
|
NT
|
NT
|
NT
|
NT
|
Neg
|
NT
|
NT
|
NT
|
4.3
|
0.4
|
0.4
|
0
|
14
|
F
|
46
|
49
|
Penicillin V
|
urt+angio (NIR)
|
4.3
|
3.4
|
1.4
|
0.5
|
0
|
0
|
Neg
|
Neg
|
NT
|
NT
|
NT
|
0
|
0
|
0
|
0
|
Neg
|
NT
|
NT
|
NT
|
9.8
|
2.8
|
2.9
|
1.3
|
15
|
F
|
34
|
38
|
Penicillin V
|
rash (NIR)
|
491.2
|
0
|
0
|
0.9
|
0
|
0
|
Neg
|
Neg
|
Neg
|
NT
|
NT
|
0
|
0
|
0
|
0
|
Neg
|
Neg
|
NT
|
NT
|
0
|
0
|
0
|
0
|
16
|
F
|
63
|
67
|
Amoxicillin
|
rash (NIR)
|
107.3
|
0.4
|
0
|
0
|
0
|
0
|
Neg
|
Neg
|
NT
|
Neg
|
NT
|
0
|
0
|
0
|
0
|
Neg
|
NT
|
Neg
|
NT
|
0
|
0
|
0
|
0
|
17
|
M
|
60
|
61
|
Amoxicillin
|
rash (NIR)
|
698.1
|
3.2
|
0
|
0
|
0
|
0
|
Neg
|
Neg
|
NT
|
NT
|
NT
|
0
|
0
|
0
|
0
|
Neg
|
NT
|
Neg
|
NT
|
0
|
0
|
0
|
0
|
18
|
F
|
60
|
67
|
Amoxicillin
|
urt (NIR)
|
NT
|
0.5
|
0
|
0
|
0
|
0
|
Neg
|
Neg
|
NT
|
Neg
|
NT
|
0
|
0
|
0
|
0
|
NT
|
NT
|
Neg
|
NT
|
0
|
0
|
0
|
0
|
19
|
M
|
52
|
52
|
Penicillin V
|
rash (NIR)
|
NT
|
0
|
0
|
0.7
|
0
|
0
|
Neg
|
Neg
|
Neg
|
NT
|
NT
|
NT
|
NT
|
NT
|
NT
|
Neg
|
Neg
|
NT
|
NT
|
NT
|
NT
|
NT
|
NT
|
20
|
F
|
56
|
61
|
Amoxicillin
|
rash (NIR)
|
NT
|
1.1
|
1.0
|
0
|
0
|
0
|
Neg
|
Neg
|
NT
|
Neg
|
NT
|
NT
|
NT
|
NT
|
NT
|
Neg
|
NT
|
Neg
|
NT
|
NT
|
NT
|
NT
|
NT
|
21
|
F
|
58
|
59
|
Amoxicillin
|
rash (NIR)
|
NT
|
0.4
|
0
|
0
|
0
|
0
|
Neg
|
Neg
|
NT
|
Neg
|
NT
|
NT
|
NT
|
NT
|
NT
|
Neg
|
NT
|
Neg
|
NT
|
NT
|
NT
|
NT
|
NT
|
22
|
F
|
35
|
43
|
Penicillin V
|
urt (NIR)
|
355.8
|
0.4
|
0
|
0
|
0
|
0
|
Neg
|
Neg
|
NT
|
NT
|
NT
|
NT
|
NT
|
NT
|
NT
|
Neg
|
NT
|
NT
|
NT
|
NT
|
NT
|
NT
|
NT
|
- *Patient data are illustrating the patients’ age at the time of respective IgE positive and IgE negative results.
- F: female, M: male, urt: urticarial, angio: angioedema, p.o.7: 7-day oral challenge, pos: positive challenge, neg: negative challenge, NT: not tested, MDM: Minor determinant mix for penicillin, \: not tested due to either positive i.v./single dose challenge or to positive post-challenge specific IgE to penicillin, bold data: positive result, 0: negative result.