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Table 4 Overview most frequent related AEs (safety population)

From: A prospective study comparing the efficacy and safety of two sublingual birch allergen preparations

Symptom/signa   SUB-B Stal-B
  Grade No. of symptoms No. of subjects % of subjects No. of symptoms No. of subjects % of subjects
Local reactions        
Pruritus/swelling of mouth, tongue or lip I 44 24 63.2 31 22 61.1
II 1 1 2.6 0 0 0
Throat irritation I 4 3 7.9 5 2 5.6
Ear pruritus I 4 4 10.5 3 1 2.8
Nausea I 3 2 5.3 0 0 0
Abdominal pain I 3 3 7.9 1 1 2.8
Systemic reactions        
Upper respiratory        
 Rhinitis (e.g., sneezing, rhinorrhea, nasal pruritus, and/or nasal congestion) I 10 5 13.2 8 6 16.7
 Cough I 2 2 5.3 1 1 2.8
Conjunctival        
 Conjunctival erythema, pruritus , or tearing I 2 2 5.3 3 2 5.6
Other        
 Headache I 1 1 2.6 3 2 5.6
  1. aSymptom/sign designation according to WAO grading of local and systemic adverse events [1618].