Table 2 Baseline values for measured hematology and blood chemistry parameters (SLIT 6-grass: n = 91 for placebo and n = 94 for active treatment; SCIT rBet v1-FV: n = 103 for placebo and n = 108 for active treatment; pre-seasonal SCIT 6-grass: n = 77 for placebo and n = 77 for active treatment)

Platelets [1000/μL]

247.5

[134.0; 401.0]

249

[148.0; 393.0]

247

[149.0; 429.0]

236

[121.0; 369.0]

249

[100.0; 462.0]

261

[152.0; 377.0]

Leukocytes [1000/μL]

6.4

[3.2; 12.5]

6.3

[3.1; 14.6]

6

[3.3; 12.8]

5.8

[3.1; 12.1]

6.5

[3.7; 11.8]

6

[3.6; 14.6]

Lymphocytes [%]

26.3

[16.5; 42.7]

27

[14.6; 47.0]

31.4

[1.7; 61.0]

33.8

[8.8; 63.0]

29

[2.5; 52.7]

31.2

[2.7; 49.1]

Basophils [%]

0.6

[0.0; 1.9]

0.6

[0.0; 1.8]

0.6

[0.0; 2.1]

0.6

[0.0; 3.7]

0.5

[0.0; 1.8]

0.7

[0.0; 3.9]

Eosinophils [%]

1.9

[0.7; 16.1]

2

[0.0; 10.5]

2.4

[0.0; 11.1]

2.7

[0.7; 8.4]

2.3

[0.3; 10.3]

2.7

[0.1; 10.7]

Monocytes [%]

6.6

[0.3; 11.2]

6.2

[3.3; 12.2]

6.6

[2.6; 13.3]

7

[2.8; 17.0]

6.9

[0.5; 16.9]

6.9

[0.9; 15.7]

Neutrophils [%]

60

[1.0; 76.2]

60

[43.0; 77.4]

58

[30.0; 92.3]

55.7

[25.0; 86.0]

58.8

[34.0; 86.8]

56.6

[38.6; 72.8]

Erythrocytes [10⁶/μL]

4.8

[3.8; 6.0]

4.8

[4.0; 6.0]

4.8

[3.8; 5.8]

4.7

[3.6; 5.5]

4.62

[3.8; 5.8]

4.65

[3.9; 5.9]

Haematocrit [%]

44

[36.9; 52.0]

44.1

[34.0; 55.2]

42

[35.0; 51.0]

41.9

[33.0; 56.0]

42

[32; 50.0]

41.1

[26.9; 52.2]

Haemoglobin [g/dL]

14.7

[12.0; 18.0]

14.9

[12.0; 18.3]

14.4

[11.6; 16.8]

14

[10.5; 17.2]

14.1

[9.9; 17.4]

14.01

[8.0; 17.3]

MCH [pg]

29.5

[21.0; 33.1]

29.7

[21.0; 90.0]

30

[25.0; 33.8]

30.3

[23.0; 34.0]

ND

ND

ND

ND

MCHC [g/dL]

32.9

[30.3; 35.5]

33.3

[29.9; 36.5]

34

[29.1; 36.2]

33.6

[27.3; 36.9]

ND

ND

ND

ND

MCV [fL]

88.8

[83.0; 103.0]

89

[76.0; 106.0]

89

[76.0; 105.0]

90

[72.0; 108.0]

ND

ND

ND

ND

Blood chemistry

Potassium [mmol/L]

4.2

[3.1; 5.4]

4.2

[3.7; 7.3]

4.2

[3.3; 6.2]

4.2

[3.1; 7.3]

4.8

[3.5; 10.0]

4.6

[3.7; 10.0]

Sodium [mmol/L]

140

[134.0; 148.4]

140

[134.0; 149.5]

140

[133.0; 147.0]

140

[127.0; 146.4]

139

[132.0; 139.0]

139.1

[133.0; 147.0]

Gamma-GT [U/L]

16

[7.0; 72.0]

19

[4.0; 243.0]

ND

ND

ND

ND

14

[5.0; 58.0]

19

[4.0; 190.2]

SGOT (AST) [U/L]

21

[6.0; 42.0]

23.5

[8.0; 62.0]

23

[8.0; 51.0]

25

[11.0; 72.0]

14.5

[5.0; 31.0]

15

[5.0; 36.0]

SGPT (ALT) [U/L]

20

[6.0; 56.0]

24

[7.0; 93.0]

22

[5.4; 84.0]

22

[6.0; 113.0]

18

[4.0; 18.0]

18.6

[5.0; 61.0]

Creatinine [mg/dL]

0.9

[0.5; 1.4]

0.9

[0.6; 1.3]

0.9

[0.5; 1.3]

0.8

[0.3; 1.3]

0.9

[0.6; 1.3]

0.9

[0.6; 1.4]

Bilirubin [mg/dL]

0.7

[0.2; 1.5]

0.7

[0.2; 3.1]

0.6

[0.1; 2.8]

0.5

[0.2; 2.5]

0.6

[0.2; 2.1]

0.6

[0.2; 2.7]

Urea [mg/dL]

29

[17.0; 53.0]

29

[19.0; 54.0]

28

[10.0; 47.0]

27

[10.0; 47.0]

26

[12.0; 52.0]

26

[6.4; 43.2]