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Table 1 Characteristics peanut sensitized patients that underwent a DBPCFC

From: Plasma IL-25 is elevated in a subgroup of patients with clinical reactivity to peanut

No

Sex

Age

Peanut-specific-IgE at diagnosis

SPT at diagnosis

Asthma#

Atopic Dermatitis$

Clinical response to DBPCFC

GI

Resp

Syst

(years)

1

M

10

4.0

<1

-

+

-

   

2

M

15

0.43

<1

+

+

-

   

3

M

16

<0.35

3

-

-

-

   

4

M

14

2.0

2

-

-

-

   

5

M

4

5.9

NP

-

-

-

   

6

F

3

0.6

3

-

+

-

   

7

M

13

1.1

2

-

+

-

   

8

M

4

7.3

<1

+

+

-

   

9

M

15

0.6

2

-

+

-

   

10

M

4

97.0

4

+

+

-

   

11

M

8

0.8

3

-

-

-

   

12

F

4

1.1

2

+

+

-

   

13

M

5

>100

4.5

-

+

+

+

+

+

14

M

9

2.2

1

+

-

+

*

*

*

15*

F

6

>100

3

-

-

+

+

+

+

16*

M

17

56.0

3.5

-

+

+

-

+

-

17

M

6

>100

4

+

-

+

+

-

-

18

F

7

1.9

4

+

+

+

+

+

-

19

M

4

3.5

NP

-

+

+

+

+

+

20

M

9

>100

3

+

-

+

+

+

+

21

M

7

55.0

3

+

+

+

+

-

-

22

F

7

2.1

4

+

+

+

+

+

+

23*

M

11

4.0

2

-

+

+

+

-

+

24

M

4

6.0

2

-

+

+

+

+

-

25*

F

6

4.9

2

-

+

+

+

+

+

26

M

7

15.5

3

-

-

+

+

-

+

27*

M

5

21.0

2

+

-

+

+

+

-

28

F

6

5.3

3

+

+

+

+

-

-

29*

M

6

2.2

NP

+

+

+

+

+

+

30

F

5

NP

2

-

+

+

-

+

-

  1. Patient no. 1–12: non-responders to peanut challenge. Patient no. 13–30: positive responders to peanut challenge. # Asthma diagnosed according to ATS criteria.
  2. $Atopic dermatitis diagnosed according to criteria from Hanifin and Rajka. SPT, Skin Prick Test (the number represents the wheal size ratio peanut compared to histamine). DBPCFC, Double-Blind Placebo-Controlled Food Challenge. NP, Not performed. *Children with elevated plasma IL-25 as determined in Figure 1.
  3. GI: Gastrointestinal symptoms including stomach ache, nausea, vomiting and diarrhea; Resp: respiratory symptoms including rhinorrhea, stuffy nose; Syst: systemic symptoms including shortage of breath, systemic urticaria and angioedema.