IgE antibody responses as measured by PCA upon intra- gastric or i. p. sensitization. 2S albumin and 2S albumin-R-specific IgE as measured by PCA tests were determined upon daily intragastric dosing of BN rats (n = 10) with water, 0.1 mg and 1 mg 2S albumin or 2S albumin-R per rat for 42 days or after i.p. sensitization (n = 5; day 28 sera), respectively. Data are given as the individual measured wheal diameter in cm (□) for each rat. Statistical differences between oral dosing groups or between i.p. dosing groups are depicted (**p < 05, ***p < 0.001).