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Table 2 Potential interference of medications with the skin test reaction (adapted from Demoly (2003) [23]; Rueff (2010) [24]and Position Paper: Allergen standardization and skin tests: The European Academy of Allergy (1993))

From: The skin prick test – European standards

Drug Suppression Abstinence before testing Reference
  0: no evidence; (+): possible, +: slight; ++: medium, +++: strong   
Antihistamines    
1st generation H1-blocker +++ > 2 days Dreborg (1989) [25]
Hydroxyzine
2nd generation H1-blocker +++ 7 days Devillier (2008) [26]
Cetirizine, Loratadine, etc.
Ketotifen +++ > 5 days  
H2-blocker 0 - + Ø  
Glucocorticosteroids    
  Topical (in test area) + > 1 week 1 Hammarlund (1990) [27], Pipkorn (1989) [28], Gradman (2008) [29]
  Nasal 0 Ø  
  Inhaled 0 Ø  
  Systemic/short term (up to 10 days) 0 / (+)   
  < 50 mg/d Prednisolone-equivalent 0 / (+) > 3 days Hammarlund (1990) [30]
  > 50 mg/d Prednisolone-equivalent (+) > 1 week 2 Des Roches (1996) [31]
  Systemic/long term (more than 10 days)    
  <10 mg/d Prednisolone-equivalent 0 Ø Olson (1990) [32]
  >10 mg/d Prednisolone-equivalent 0 > 3 weeks 2 Des Roches (1996) [31]
  Topical calcineurin inhibitors + > 1 week Gradman (2008) [29]
Other systemic drugs    
Omalizumab ++ > 4 weeks Noga (2003) [33]
Leukotriene receptor antagonist 0 Ø Cuhadaroglu (2001) [34], Hill (2003) [35]
Cyclosporin A 0 Ø Munro (1991) [36]
Theophylline 0 Ø Spector (1979) [37]
Antidepressants    
  Doxepin ++ 7 days Rao (1988) [38]
  Desipramine ++ 3 days Rao (1988) [38]
  SSRI: Citalopram, Fluoxetin, Sertralin 0 Ø Isik (2011) [39]
β-adrenergic agonists 0 Ø Abramowitz (1980) [40], Spector (1979) [39]
  Salbutamol, Salmeterol, Bambuterol,       Terbutalin 0   Petersen (2003) [41]
  1. 1 Depends on dosage and length of treatment (> 3 weeks).
  2. 2 A retrospective study showed no influence of the skin reaction by 10–60 mg prednisone for 2 or more years.