A qPCR-based metric of Th2 airway inflammation in asthma

Table 1 Baseline subject characteristics

	Healthy controls	Asthmatics	p value
Sample size of qPCR data	19	24
Age, years	34 ± 9	33 ± 12	0.71
BMI	26 ± 4	28 ± 5	0.20
Gender (% F)	42	50	0.84
Ethnicity*
White	10	10
African-American	1	2
Hispanic	3	6
Asian/Pacific Islander	4	5
Native American	1	1
FEV₁, % predicted	99 ± 13	84 ± 13	0.0008
Δ FEV₁ with albuterol (% of baseline)	5.0 ± .4.5	14.4 ± 9.5	0.0001
FEV₁/FVC	0.78 ± 0.066	0.73 ± 0.074	0.02
Methacholine PC₂₀ (mg/ml)	> 10 (n = 18)	0.57 (0.07-4.40)	<0.0001
IgE, IU/ml	20 (4–357), (n = 18)	232 (2–6556)	<0.0001
Blood eosinophils, ×10⁹/L	0.11 (0.04-0.30)	0.33 (0.05-0.75)	<0.0001
FeNO	16 (9–49)	62 (9–144), (n = 18)	0.0004

Values reported as mean ± standard deviation, or median (range). All data are from the baseline visit except spirometry, which are reported from visit 2 (immediately before initiation of ICS). p- values are based on t-test or chi-square test for proportions unless otherwise noted.
* In cases of multiple ethnicities, the lowest-numbered ethnicity from this list is reported: 1. Hispanic, 2. Black, 3. Pacific Islander, 4. Native American, 5. Asian, 6. White.

ISSN: 2045-7022