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Table 5 Clinical features and results of patients with positive first COX-2 inhibitor challenge

From: Tolerance to alternative cyclooxygenase-2 inhibitors in nonsteroidal anti-inflammatory drug hypersensitive patients

Patient no. Sex/age Co-morbid disorders Culprit drug Paracetamol intolerance Type of reaction Manner of diagnosis Reaction to oral COX-2 inhibitor challenges
First Second
Drug Reaction Drug Reaction
1 F/55 As diclofenac no U/A/Ana PH; repRX rofecoxib U/D nd  
2 M/78 NS diclofenac no A/D/Ana C rofecoxib U nd  
3 F/65 As multiple no U PH; repRX celecoxib U rofecoxib Neg
4 F/55 NS diclofenac no U/Ana C rofecoxib A celecoxib Neg
5 F/46 NS naproxen no A PH rofecoxib A celecoxib Neg
6 M/36 NS multiple yes U/A PH; repRX celecoxib U nd  
7 F/35 NS multiple no U/A C etoricoxib U/A celecoxib Neg
8 F/51 As diclofenac no A/D PH; repRX celecoxib U/An/D/A nd  
9 F/56 NS multiple yes A C, repRX celecoxib A rofecoxib Neg
10 F/50 NS naproxen no U/Ana PH; repRX celecoxib A etoricoxib Neg
11 F/59 NS naproxen no U/A PH; repRX celecoxib A etoricoxib Neg
12 F/46 NS diclofenac no U/A/D/Ana PH celecoxib A etoricoxib Neg
13 F/62 U multiple yes U/A PH; repRX celecoxib U nd  
14 M/40 U ibuprofen yes U/A PH; repRX celecoxib U/D etoricoxib U/D
15 F/66 NS diclofenac no U/A/D/Ana PH; repRX celecoxib U/A etoricoxib Neg
16 F/63 NS multiple no U/A/ D PH; repRX celecoxib U/A etoricoxib Neg
17 F/53 NS diclofenac no U C celecoxib U/A etoricoxib U/A/D
18 F/46 A/U multiple no U/A PH; repRX celecoxib A etoricoxib Neg
19 M49 NS diclofenac no U/A PH celecoxib U/A etoricoxib Neg
  1. Legend: F, female; M, male; NS, none specific; As, asthma; U, urticaria; A, angioedema (without weals); Ana, anaphylactic shock; D, dyspnea; PH, patient history; repRx, repeated reaction to the same drug; C, challenge test; nd, not done; Neg, negative reaction. 2 patients with a positive challenge to a second COX-2 inhibitor are highlighted in bold.