Tolerance to alternative cyclooxygenase-2 inhibitors in nonsteroidal anti-inflammatory drug hypersensitive patients

Table 5 Clinical features and results of patients with positive first COX-2 inhibitor challenge

Patient no.	Sex/age	Co-morbid disorders	Culprit drug	Paracetamol intolerance	Type of reaction	Manner of diagnosis	Reaction to oral COX-2 inhibitor challenges
							First		Second
							Drug Reaction		Drug Reaction
1	F/55	As	diclofenac	no	U/A/Ana	PH; repRX	rofecoxib	U/D	nd
2	M/78	NS	diclofenac	no	A/D/Ana	C	rofecoxib	U	nd
3	F/65	As	multiple	no	U	PH; repRX	celecoxib	U	rofecoxib	Neg
4	F/55	NS	diclofenac	no	U/Ana	C	rofecoxib	A	celecoxib	Neg
5	F/46	NS	naproxen	no	A	PH	rofecoxib	A	celecoxib	Neg
6	M/36	NS	multiple	yes	U/A	PH; repRX	celecoxib	U	nd
7	F/35	NS	multiple	no	U/A	C	etoricoxib	U/A	celecoxib	Neg
8	F/51	As	diclofenac	no	A/D	PH; repRX	celecoxib	U/An/D/A	nd
9	F/56	NS	multiple	yes	A	C, repRX	celecoxib	A	rofecoxib	Neg
10	F/50	NS	naproxen	no	U/Ana	PH; repRX	celecoxib	A	etoricoxib	Neg
11	F/59	NS	naproxen	no	U/A	PH; repRX	celecoxib	A	etoricoxib	Neg
12	F/46	NS	diclofenac	no	U/A/D/Ana	PH	celecoxib	A	etoricoxib	Neg
13	F/62	U	multiple	yes	U/A	PH; repRX	celecoxib	U	nd
14	M/40	U	ibuprofen	yes	U/A	PH; repRX	celecoxib	U/D	etoricoxib	U/D
15	F/66	NS	diclofenac	no	U/A/D/Ana	PH; repRX	celecoxib	U/A	etoricoxib	Neg
16	F/63	NS	multiple	no	U/A/ D	PH; repRX	celecoxib	U/A	etoricoxib	Neg
17	F/53	NS	diclofenac	no	U	C	celecoxib	U/A	etoricoxib	U/A/D
18	F/46	A/U	multiple	no	U/A	PH; repRX	celecoxib	A	etoricoxib	Neg
19	M49	NS	diclofenac	no	U/A	PH	celecoxib	U/A	etoricoxib	Neg

Legend: F, female; M, male; NS, none specific; As, asthma; U, urticaria; A, angioedema (without weals); Ana, anaphylactic shock; D, dyspnea; PH, patient history; repRx, repeated reaction to the same drug; C, challenge test; nd, not done; Neg, negative reaction. 2 patients with a positive challenge to a second COX-2 inhibitor are highlighted in bold.

ISSN: 2045-7022