|
Patient no.
|
Sex/age
|
Co-morbid disorders
|
Culprit drug
|
Paracetamol intolerance
|
Type of reaction
|
Manner of diagnosis
|
Reaction to oral COX-2 inhibitor challenges
|
|---|
|
First
|
Second
|
|---|
|
Drug Reaction
|
Drug Reaction
|
|---|
|
1
|
F/55
|
As
|
diclofenac
|
no
|
U/A/Ana
|
PH; repRX
|
rofecoxib
|
U/D
|
nd
| |
|
2
|
M/78
|
NS
|
diclofenac
|
no
|
A/D/Ana
|
C
|
rofecoxib
|
U
|
nd
| |
|
3
|
F/65
|
As
|
multiple
|
no
|
U
|
PH; repRX
|
celecoxib
|
U
|
rofecoxib
|
Neg
|
|
4
|
F/55
|
NS
|
diclofenac
|
no
|
U/Ana
|
C
|
rofecoxib
|
A
|
celecoxib
|
Neg
|
|
5
|
F/46
|
NS
|
naproxen
|
no
|
A
|
PH
|
rofecoxib
|
A
|
celecoxib
|
Neg
|
|
6
|
M/36
|
NS
|
multiple
|
yes
|
U/A
|
PH; repRX
|
celecoxib
|
U
|
nd
| |
|
7
|
F/35
|
NS
|
multiple
|
no
|
U/A
|
C
|
etoricoxib
|
U/A
|
celecoxib
|
Neg
|
|
8
|
F/51
|
As
|
diclofenac
|
no
|
A/D
|
PH; repRX
|
celecoxib
|
U/An/D/A
|
nd
| |
|
9
|
F/56
|
NS
|
multiple
|
yes
|
A
|
C, repRX
|
celecoxib
|
A
|
rofecoxib
|
Neg
|
|
10
|
F/50
|
NS
|
naproxen
|
no
|
U/Ana
|
PH; repRX
|
celecoxib
|
A
|
etoricoxib
|
Neg
|
|
11
|
F/59
|
NS
|
naproxen
|
no
|
U/A
|
PH; repRX
|
celecoxib
|
A
|
etoricoxib
|
Neg
|
|
12
|
F/46
|
NS
|
diclofenac
|
no
|
U/A/D/Ana
|
PH
|
celecoxib
|
A
|
etoricoxib
|
Neg
|
|
13
|
F/62
|
U
|
multiple
|
yes
|
U/A
|
PH; repRX
|
celecoxib
|
U
|
nd
| |
|
14
|
M/40
|
U
|
ibuprofen
|
yes
|
U/A
|
PH; repRX
|
celecoxib
|
U/D
|
etoricoxib
|
U/D
|
|
15
|
F/66
|
NS
|
diclofenac
|
no
|
U/A/D/Ana
|
PH; repRX
|
celecoxib
|
U/A
|
etoricoxib
|
Neg
|
|
16
|
F/63
|
NS
|
multiple
|
no
|
U/A/ D
|
PH; repRX
|
celecoxib
|
U/A
|
etoricoxib
|
Neg
|
|
17
|
F/53
|
NS
|
diclofenac
|
no
|
U
|
C
|
celecoxib
|
U/A
|
etoricoxib
|
U/A/D
|
|
18
|
F/46
|
A/U
|
multiple
|
no
|
U/A
|
PH; repRX
|
celecoxib
|
A
|
etoricoxib
|
Neg
|
|
19
|
M49
|
NS
|
diclofenac
|
no
|
U/A
|
PH
|
celecoxib
|
U/A
|
etoricoxib
|
Neg
|
- Legend: F, female; M, male; NS, none specific; As, asthma; U, urticaria; A, angioedema (without weals); Ana, anaphylactic shock; D, dyspnea; PH, patient history; repRx, repeated reaction to the same drug; C, challenge test; nd, not done; Neg, negative reaction. 2 patients with a positive challenge to a second COX-2 inhibitor are highlighted in bold.
