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Table 1 Challenge protocols of culprit NSAIDs

From: Tolerance to alternative cyclooxygenase-2 inhibitors in nonsteroidal anti-inflammatory drug hypersensitive patients

  Diclofenac Ibuprofen Aspirin Naproxen Propyfenazon
Administration oral oral oral oral oral
Dose 1 (mg) 0.1 0.1 10 0.1 1
Dose 2 (mg); time interval (min) 1; 30 1; 30 44; 30 1; 30 5; 30
Dose 3 (mg); time interval (min) 10; 30 10; 30 117; 60 10; 30 25; 30
Dose 4 (mg); time interval (min) 25; 60 50; 30 312; 60 50; 30 100; 60
Dose 5 (mg); time interval (min) 50; 60 100; 60 500; 120 125; 30 250; 60
Dose 6 (mg); time interval (min) NA 200; 60 NA 250; 60 NA
  1. Legend: Min, minutes; NA, not applicable; (Since this study the dosages have been revised and the dosage of 0.1 mg is removed.)