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Table 2 Late local and systemic reactions per injection and per patient in each up-dosing regimen and the highest dose reached

From: Open-label parallel dose tolerability study of three subcutaneous immunotherapy regimens in house dust mite allergic patients

Regimen

Total injections (n)

LLR n (%) injections

LLR n (%) patients

SR n (%) injections

SR n (%) patients

Highest dose reached n (%) patients [95% CI]

Regular (n=5)

73

5 (7)

2 (40.0)

4 (5)

4 (80.0)

4 (80.0)

[44.9-100]

Intermediate (n=19)

221

24 (11)

11 (57.9)

23 (10)

9 (47.4)

16 (84.2)

[67.8-100]

Fast (n=15)

146

23 (16)

10 (66.7)

4 (3)

3 (20.0)

13 (86.7)

[69.5-100]

Overall (n=39)

440

52 (12)

23 (59.0)

31 (7)

16 (41.0)

33 (84.6)

[73.3-95.9]

  1. LLR= late local reaction (swelling > 5 cm), SR= systemic reaction (grade 1, early and late), CI=confidence interval.