Systemic responses induced in mice after oral sensitization and epicutaneous immunotherapy (a) Quantity of specific IgE and (b) specific IgG2a expressed in μg/ml. Data are expressed as means ± SD for each group, D42 after oral sensitization, D106 after immunotherapy and sustained peanut exposure. (c) Measurement of histamine release in bloodstream after oral challenge to peanuts. Data are expressed as means ± SD for each group. * p<0.05, ** p<0.01, *** p<0.001.