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Table 5 Effect of vitamin C on the FEV1 levels of asthmatic children

From: Vitamin C and asthma in children: modification of the effect by age, exposure to dampness and the severity of asthma

Subgroup

No. of Children

FEV1

Mean (L/s)

Change in FEV1

Test for interaction (P)

  

Placebo

Vitamin C

Estimate

95% CI

 

All

60

1.125

1.446

28.9%

27.3-30.4%

 

C-ACT at baseline

      

13-15

30

1.16

1.48

27.5%

25.4-29.6%

0.07a)

16-19

30

1.09

1.41

30.3%

28.0-32.6%

 

FEV1/FVC (%)

      

< 59

28

1.11

1.43

29.4%

27.0-31.9%

0.5a)

≥59

32

1.14

1.46

28.4%

26.3-30.5%

 

FEV1 at baseline (L/s)

      

< 1.1

29

1.00

1.31

31.1%

28.6-33.6%

0.004a)

≥1.1

31

1.24

1.58

26.8%

25.1-28.5%

 

Age (yr)

      

7.0-8.2

30

1.00

1.31

31.1%

28.7-33.5%

0.003a)

8.3-10

30

1.25

1.58

26.7%

24.9-28.4%

 

Weight (kg)

      

23-28

29

1.12

1.44

29.7%

27.1-32.3%

0.3a)

29-37

31

1.13

1.45

28.1%

26.2-30.0%

 

Gender

      

Girl

22

1.07

1.37

28.6%

25.6-31.6%

0.8

Boy

38

1.16

1.49

29.0%

27.2-30.9%

 

Dampness exposure

      

Never

25

1.16

1.53

32.4%

30.2-34.6%

0.001b)

During past 1 yr

20

1.11

1.42

27.6%

25.9-29.4%

 

Earlier

14

1.07

1.34

25.0%

21.2-28.8%

 

Smoking by the father

      

Never

21

1.17

1.52

30.1%

28.0-32.2%

0.4c)

Current

22

1.08

1.38

28.5%

25.3-31.7%

 

Ex-smoker

17

1.12

1.43

27.9%

24.9-30.9%

 

Residential area

      

Urban

34

1.09

1.40

29.2%

27.2-31.3%

0.6

Rural

26

1.17

1.50

28.4%

25.8-31.0%

 
  1. a) The test of interaction was calculated by using dichotomized variables for the C-ACT, FEV1/FVC ratio, FEV1, age, and weight (cut points at the medians). The test of interaction by using the continuous variables gives P = 0.2 for the baseline C-ACT and P = 0.001 for age.
  2. b) The test of interaction is restricted to the "Never" and "During past 1 yr" subgroups. One child who was exposed to dampness both "During past 1 yr" and "Earlier" is excluded from this subgroup comparison.
  3. c) The test of interaction is restricted to the "Never" and "Current" subgroups.