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Table 2 Comparison of FeNO values between groups in the 18 studies included

From: Effects of atopy and rhinitis on exhaled nitric oxide values - a systematic review

 

Studies in Children (n = 8)

Studies in Adults (n = 11)

 

Mean

(n = 4)

Median

(n = 2)

Values not shown (n = 2)

Mean

(n = 3)

Median

(n = 6)

Values not shown (n = 2)

 

Hervás 2008[8]

Hung 2007[22]

Malmberg 2006[21]

Saito 2004[28]

Cardinale 2005[11]

Cibella 2008[12]

Marcucci 2007[23]

Profita 2006[13]

Prieto 2002[29]

Prieto, 2002[16]

Rolla 2007[30]

Rouhos 2008[31]

Kostikas 2008[32]

Tanou 2009[33]

Berlyne 2000[14]

Gratziou

2008[34]

Olin 2004[35]

Aronsson 2005[36]

Mansson 2009[37]

FeNO Value s

Atopic

19 (1.21)

-

14.6‡

33.3 (1.13)

-

17.4

(5.5-95.2)*

FeNO values

not present§

-

-

-

13.2

-

-

11 (6)

.

16.5

(11.3-27.6)

FeNO values

not present§

AR

26.3 (1.04)

24.68 (19.2)

-

-

15.3

(9.4-31.0)

19.1

(5.8-92.5)*

  

25.1

(5.7-102.9)

DS: 63.1(1.26) OS: 30.2(1.27)

24.5

(3.32)

23.0

(11.6-43.6)*

17.0

(12.5-23.0)

20.5

(12.5-33)

-

12.5

(4.0-50.0)

31.0

(16.0-50.5)

  

NAR

-

-

-

-

-

12.6

(2.8-71.8)*

  

-

-

16.1‡

-

-

-

-

-

19.2

(14.1-22.0)

  

Healthy

7.9 (0.96)

9.44 (3.97)

10.3‡

15.1 (1.14)

5.9

(3.4-9.3)

13.1

(3.0-71.0)*

  

11.2

(5.0-31.5)

**

12.6 (1.4)

13.5

(0.9)

15.5 †

10.5

(7.0-13.0)

9.5

(8.0-12.0)

9 (7)

3.8

(1.0-7.3)

15.8

(11.9-21.4)

  

Comparison of FeNO values between ||

Atopic and Healthy

↑↑

-

↑↑

-

-

-

-

-

-

NS (↓)

-

-

NS (↑)

-

NS (↑)

-

-

AR and Healthy

↑↑↑

↑↑↑

-

-

↑↑↑

NS (↑)

NS (↔)

↑↑

E:↑↑↑

NE:↑↑

↑↑

NR (↑)

↑↑

↑↑

-

↑↑↑

NR (↑↑)

NS (↔)

NAR and Healthy

-

-

-

-

-

NS (↓)

-

-

-

-

NS (↑)

-

-

-

-

-

NR (↑↑)

-

-

AR and Atopic

-

-

-

-

NS (↑)

-

-

-

-

-

NR (↑↑)

-

-

-

-

↑↑

-

-

AR and NAR

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

Atopic and NAR

-

-

-

-

-

NS (↑)

-

-

-

-

-

-

-

-

-

-

NR (↓)

-

-

  1. Values are presented as Mean (SD) or as Median (Interquartil Range), otherwise indicated: *Median (Range), †Mean (Range), ‡ Dispersion Measure not presented, §The studies' reports do not included numerical results. ||Comparison was based in a ratio between FeNO values in each group: 1, 2 or 3 arrows means a ratio increase/decrease on FeNO values of 1,2 or 3 or more times, respectively. DS: During Season OS: Out of Season. Adult classification was defined as a mean/median age value ≥18 years. Atopic was defined as presence of allergic sensitization without asthma and without rhinitis. All comparisons are statistically significant (p < 0.05), otherwise indicated. NR: Statistical significance not reported. NS: Not significant.