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Table 2 Comparison of FeNO values between groups in the 18 studies included

From: Effects of atopy and rhinitis on exhaled nitric oxide values - a systematic review

  Studies in Children (n = 8) Studies in Adults (n = 11)
  Mean
(n = 4)
Median
(n = 2)
Values not shown (n = 2) Mean
(n = 3)
Median
(n = 6)
Values not shown (n = 2)
  Hervás 2008[8] Hung 2007[22] Malmberg 2006[21] Saito 2004[28] Cardinale 2005[11] Cibella 2008[12] Marcucci 2007[23] Profita 2006[13] Prieto 2002[29] Prieto, 2002[16] Rolla 2007[30] Rouhos 2008[31] Kostikas 2008[32] Tanou 2009[33] Berlyne 2000[14] Gratziou
2008[34]
Olin 2004[35] Aronsson 2005[36] Mansson 2009[37]
FeNO Value s
Atopic 19 (1.21) - 14.6‡ 33.3 (1.13) - 17.4
(5.5-95.2)*
FeNO values
not present§
- - - 13.2 - - 11 (6) . 16.5
(11.3-27.6)
FeNO values
not present§
AR 26.3 (1.04) 24.68 (19.2) - - 15.3
(9.4-31.0)
19.1
(5.8-92.5)*
   25.1
(5.7-102.9)
DS: 63.1(1.26) OS: 30.2(1.27) 24.5
(3.32)
23.0
(11.6-43.6)*
17.0
(12.5-23.0)
20.5
(12.5-33)
- 12.5
(4.0-50.0)
31.0
(16.0-50.5)
  
NAR - - - - - 12.6
(2.8-71.8)*
   - - 16.1‡ - - - - - 19.2
(14.1-22.0)
  
Healthy 7.9 (0.96) 9.44 (3.97) 10.3‡ 15.1 (1.14) 5.9
(3.4-9.3)
13.1
(3.0-71.0)*
   11.2
(5.0-31.5)
**
12.6 (1.4) 13.5
(0.9)
15.5 † 10.5
(7.0-13.0)
9.5
(8.0-12.0)
9 (7) 3.8
(1.0-7.3)
15.8
(11.9-21.4)
  
Comparison of FeNO values between ||
Atopic and Healthy ↑↑ - ↑↑ - - - - - - NS (↓) - - NS (↑) - NS (↑) - -
AR and Healthy ↑↑↑ ↑↑↑ - - ↑↑↑ NS (↑) NS (↔) ↑↑ E:↑↑↑
NE:↑↑
↑↑ NR (↑) ↑↑ ↑↑ - ↑↑↑ NR (↑↑) NS (↔)
NAR and Healthy - - - - - NS (↓) - - - - NS (↑) - - - - - NR (↑↑) - -
AR and Atopic - - - - NS (↑) - - - - - NR (↑↑) - - - - ↑↑ - -
AR and NAR - - - - - - - - - - - - - - - -
Atopic and NAR - - - - - NS (↑) - - - - - - - - - - NR (↓) - -
  1. Values are presented as Mean (SD) or as Median (Interquartil Range), otherwise indicated: *Median (Range), †Mean (Range), ‡ Dispersion Measure not presented, §The studies' reports do not included numerical results. ||Comparison was based in a ratio between FeNO values in each group: 1, 2 or 3 arrows means a ratio increase/decrease on FeNO values of 1,2 or 3 or more times, respectively. DS: During Season OS: Out of Season. Adult classification was defined as a mean/median age value ≥18 years. Atopic was defined as presence of allergic sensitization without asthma and without rhinitis. All comparisons are statistically significant (p < 0.05), otherwise indicated. NR: Statistical significance not reported. NS: Not significant.