Table 3 Membrane-bound receptors associated with lipid raft and/or caveolae and displaying upregulated transcript expression levels in allergic compared to healthy conjunctival specimens.

ARBK1,

Beta-adrenergic receptor kinase 1

Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors.

CD59,

CD59 glycoprotein

Potent inhibitor of the complement membrane attack complex (MAC) action. Involved in signal transduction for T-cell activation complexed to a protein tyrosine kinase.

EFNB3,

Ephrin-B3

May play a pivotal role in forebrain function. Binds to, and induces the collapse of, commissural axons/growth cones in vitro.

EPHA1,

Ephrin type-A receptor 1

Receptor for members of the ephrin-A family. Binds with a low affinity to ephrin-A1

P2RY4,

P2Y purinoceptor 4

Receptor for UTP and UDP coupled to G-proteins that activate a phosphatidylinositol-calcium second messenger system.

SSR4,

Somatostatin receptor type 4

The activity of this receptor is mediated by G proteins, which inhibit adenylyl cyclase.

TNFL8,

Tumor necrosis factor ligand superfamily member 8

Cytokine that binds to TNFRSF8/CD30. Induces proliferation of T-cells.

TRPA1,

Transient receptor potential cation channel subfamily A member 1

Has a central role in the pain response to endogenous inflammatory mediators and to a diverse array of volatile irritants, such as mustard oil, garlic and capsaicin.