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Table 2 Bet v 1-associated nasal epithelial proteins found in the allergic, but not in the healthy subjects.

From: Allergy as an epithelial barrier disease

Proteins found in caveolae and lipid rafts.

 

Name

Functions

ACTG, gamma actin

A subunit of microfilaments, one of the three major components of the cytoskeleton

ANXA2, Annexin 2

Belongs calcium-binding proteins, suppresses phospholipase A2 and thus inhibits inflammation.

CALM, Calmodulin

Belongs calcium-binding proteins, regulation of nuclear transport.

KCNA5

Voltage-dependent potassium ion permeability, has a role in regulating the secretion of insulin

PLEC1, Plectin

Intermediate filament binding protein

STML2, Stomatin 2

Colocalized at intercellular junctions and regulated gap junctions and lipid domain organization.

Other epithelial proteins

 

Name

Functions

CROCC, Ciliary rootlet

A cytoskeletal-like structure in ciliated cells

DCD, Dermcidin

Displays antimicrobial activity thus limiting infection by potential pathogens, such as E.coli and S.aureus.

ECHB

Participates in lipid metabolism.

EPIPL, Epiplakin

A cytoskeletal linker protein, interactions between epiplakin and intermediate filaments

GNDS, Ral/RalBP1

Plays a role in endocytosis and vesicle sorting and migration.

K1C18, Cytokeratin 18

A subunit of intermediate filament, one of the three major components of the cytoskeleton

MARCO

Scavenger receptor, a major mediator of non-opsonized E. coli phagocytosis clearance of bacteria in vivo

MYCB2

Mediates ubiquitination and subsequent proteasomal degradation of target proteins

S100P

Overexpressed in epithelium in psoriasis, wound healing, skin cancer, inflammation, calcium-binding

TBA8, Alpha-tubulin

The major constituent of microtubules, one of the three major components of the cytoskeleton.