Indoleamine 2,3-dioxygenase expression in patients with allergic rhinitis: a case-control study

Table 2 Characteristics of nasal specimens

	Control winter n = 7	spring n = 11	P value¹	Atopy winter n = 11	spring n = 8	P value¹	P value²
Symptom score
median	0	0	NS	0	2.0	.031	w NS*
Q1-Q3	0-0	0-0		0-0	1-2		s .003*
Inflammation score
median	1.5	1.5	NS	1.0	1.5	NS	w NS*
Q1-Q3	1-2	1-2		1-2	1-3		s NS*
No. of leukocytes/mm²
median	640	1328	NS	1344	1328	NS	w NS
Q1-Q3	384-896	1280-1376		1120-1408	992-1760		s NS
No. of eosinophils/mm²
median	96	168	NS	144	248	NS	w NS
Q1-Q3	48-144	112-224		128-160	192-448		s .044
Percentage of eosinophils
median	14.3	12.5	NS	12.0	25.5	NS	w NS
Q1-Q3	12.5-16.1	8.8-16.3		9.1-12.5	12.9-29.0		s NS
Percentage of IDO⁺ eosinophils
median	0.0	0.0	NS	0.0	0.0	NS	w NS
Q1-Q3	0.0-0.0	0.0-0.0		0.0-2.5	0.0-5.5		s NS
No. specimens with
epithelial IDO⁺	2	2	NS	1	2	NS	w NS* s NS*

Patient characteristics and results of specimens taken from the nasal cavity. Control = mucosa from inferior turbinate from patient without inflammation of nasal mucosa and without sinonasal disease, P value¹ = by pair-wise comparison between winter and spring by Wilcoxon test; P value² = comparison between control and atopy groups either in winter (w) or in spring (s) by *Fisher's exact test (discrete) or Kruskal Wallis test (continuous).

ISSN: 2045-7022