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Table 7 Independent associates of lung function and AHR (multivariate analysis)

From: Quantification of atopy, lung function and airway hypersensitivity in adults

FEV1 % predicted

Associate

Model 1 (SPT-WMD)

Model 2 (sIgE level)

 

Adj p

Adj R2

Adj p

Adj R2

Age

5.82×10-7

0.04

5.91×10-8

0.04

BMI

0.09

 

0.48

 

Current Asthma

1.64×10-14

0.08

3.34×10-24

0.14

Ln Smoke-Pack-Years

0.02

0.008

0.02

0.008

Ln Can f 1 exposure

0.06

 

0.07

 

Mite

0.16

 

0. 69

 

Cat

0.91

 

0.46

 

Dog

0.003

0.01

0.10

 

Grass

1.00

 

NI

 

Mould

0.11

 

NA

 

FVC % predicted

Associate

Model 1 (SPT-WMD)

Model 2 (sIgE level)

 

Adj p

Adj R 2

Adj p

Adj R 2

Age

0.01

0.009

0.01

0.009

BMI

3.65×10-5

0.03

6.23×10-5

0.02

Gender - female

0.0003

0.02

0.001

0.02

Current Asthma

0.0002

0.02

2.91×10-8

0.04

Ln Smoke-Pack-Years

0.44

 

0.45

 

Ln Can f 1 exposure

0.18

 

0.13

 

Mite

0.49

 

NI

 

Cat

0.91

 

NI

 

Dog

0.047

0.006

0.56

 

Grass

0.94

 

NI

 

FEV 1 /FVC

Associate

Model 1 (SPT-WMD)

Model 2 (sIgE level)

 

Adj p

Adj R 2

Adj p

Adj R 2

Age

9.99×10-20

0.12

2.51×10-23

0.13

Gender - female

0.02

0.008

0.01

0.009

Current Asthma

8.08×10-15

0.09

8.52×10-21

0.12

Ln Smoke-Pack-Years

0.004

0.01

0.004

0.01

Ln Can f 1 exposure

0.20

 

0.33

 

Ln Fel d 1 exposure

0.27

 

0.24

 

Mite

0.02

0.008

0.21

 

Cat

0.84

 

0.72

 

Dog

0.003

0.01

0.47

 

Grass

0.96

 

NI

 

Mould

0.23

 

NA

 

tMDRS

Associate

Model 1 (SPT-WMD)

Model 2 (sIgE level)

 

Adj p

Adj R 2

Adj p

Adj R 2

Gender - female

3.59×10-13

0.09

3.97×10-13

0.09

Current Asthma

3.82×10-7

0.05

0.0003

0.02

FEV 1 % predicted

60.3×10-9

0.06

1.04×10-8

0.06

FEV 1 /FVC

0.001

0.02

2.05×10-5

0.03

Ln Can f 1 exposure

0.25

 

0.32

 

Mite

0.0001

0.03

0.0004

0.02

Cat

0.36

 

0.45

 

Dog

0.56

 

0.44

 

Grass

0.20

 

0.007

0.01

Mould

0.30

 

NA

 
  1. Models using quantitative measures of sensitisation to inhalant allergens: either SPT-WMD in mm for Model 1 or level of sIgE in kUA/l for Model 2.
  2. BMI - body mass index; tMDRS - transformed methacholine dose-response slope (tMDRS = 100/(MDRS+10); SPT - skin prick tests; sIgE - serum specific IgE.
  3. Current Asthma - Physician-diagnosed asthma with asthma symptoms and/or use of asthma medication in the last 12 months[26].
  4. NA - not available; NI - not included in model (no association in univariate analysis)
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Clinical and Translational Allergy

ISSN: 2045-7022

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