Table 3 Systemic diseases accompanied by generalized pruritus/urticaria

Liver diseases

Primary biliary cirrhosis

Primary sclerosing cholangitis

Extrahepatic cholestasis

Heptatits B and C

Kidney diseases

Chronic kidney insufficiency

Hematologic diseases

Polycythemia vera

Hodgkin disease

Non-Hodgkin lymphomas

Leukemias

Myeloma Multiplex

Iron deficiency

Systemic mastocytosis

Hypereosinophilic syndrome

Myelodysplastic syndromes

Endocrine disorders

Diabetes

Hyperthyroidism

Hypothyroidism

Hyperparathyroidism

Neurologic diseases (neuropathic pruritus)

Brain injury/tumor (frequently unilateral pruritus)

Sclerosis multiplex

Small fiber neuropathy

Solid tumors (paraneoplasic pruritus)

Carcinoid syndrome

Infectious diseases

HIV infection/AIDS

Infestations