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Table 3 Systemic diseases accompanied by generalized pruritus/urticaria

From: Allergic diseases in the elderly

Liver diseases Primary biliary cirrhosis
  Primary sclerosing cholangitis
  Extrahepatic cholestasis
  Heptatits B and C
Kidney diseases Chronic kidney insufficiency
Hematologic diseases Polycythemia vera
  Hodgkin disease
  Non-Hodgkin lymphomas
  Leukemias
  Myeloma Multiplex
  Iron deficiency
  Systemic mastocytosis
  Hypereosinophilic syndrome
  Myelodysplastic syndromes
Endocrine disorders Diabetes
  Hyperthyroidism
  Hypothyroidism
  Hyperparathyroidism
Neurologic diseases (neuropathic pruritus) Brain injury/tumor (frequently unilateral pruritus)
  Sclerosis multiplex
  Small fiber neuropathy
Solid tumors (paraneoplasic pruritus)  
Carcinoid syndrome  
Infectious diseases HIV infection/AIDS
  Infestations
  1. Adapted from Reich A et al. [48]