Volume 5 Supplement 2

Abstracts from the 2nd International Severe Asthma Forum (ISAF)

Open Access

Vocal cord dysfunction diagnosis may be improved by a screening questionnaire

  • Marcelo Vivolo Aun1,
  • Lucia Helena Eduardo Pinto2,
  • Jorge Kalil2,
  • Rosana Câmara Agondi2 and
  • Pedro Giavina-Bianchi2
Clinical and Translational Allergy20155(Suppl 2):P12

DOI: 10.1186/2045-7022-5-S2-P12

Published: 23 March 2015

Background

Many patients with vocal cord dysfunction, with or without asthma, receive inappropriate treatment because they are misdiagnosed as having difficult-to-control asthma alone. We developed a clinical screening questionnaire designed to aid the diagnosis of vocal cord dysfunction.

Method

A prospective observational study involving 80 patients aged ≥ 18 years, diagnosed with severe asthma. After anamnesis, physical examination, and application of a questionnaire with 6 questions to identify vocal cord dysfunction.<TABLE01> Then patients underwent spirometry and laryngoscopy. On the basis of the laryngoscopic findings, we created three patient groups: vocal cord dysfunction (vocal cord adduction during inspiration, n=14); unconfirmed vocal cord dysfunction (inconclusive findings, n=29); and control (normal findings, n=37). We attempted to determine whether any of those groups were associated with the responses to individual questions or sets of questions on the questionnaire.

Results

The proportion of affirmative answers to the question “Does pulmonary auscultation reveal wheezing predominantly in the cervical region, or stridor?” was significantly higher for the vocal cord dysfunction group than for the other two groups (P=0.006). The control group was significantly different from the other two groups in terms of the variable “4 or more affirmative answers” (P=0.022).

Conclusion

A finding of wheezing or stridor on auscultation of the cervical region is suggestive of vocal cord dysfunction, especially in elderly patients, and such dysfunction can be confirmed through laryngoscopy. Our screening questionnaire proved effective in discriminating between patients with vocal cord dysfunction and those without.

Authors’ Affiliations

(1)
Clinical Immunology and Allergy Division, University of Sao Paulo School of Medicine
(2)
Clinical Immunology and Allergy Division, University of Sao Paulo School of Medicine

Copyright

© Aun et al; licensee BioMed Central Ltd. 2015

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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