Volume 5 Supplement 2

Abstracts from the 2nd International Severe Asthma Forum (ISAF)

Open Access

Pretreatment by omalizumab allows allergen-specific immunotherapy in children and young adult with severe allergic asthma

  • Nathalie Lambert1,
  • Tamazoust Guiddir1,
  • Jocelyne Just1 and
  • Flore Amat1
Clinical and Translational Allergy20155(Suppl 2):P1

DOI: 10.1186/2045-7022-5-S2-P1

Published: 23 March 2015

Background

Subcutaneous allergen-specific immunotherapy (SCIT) is a valuable treatment option for patients with controlled mild to moderate allergic asthma However, SCIT is contraindicated for patients with severe persistent asthma due to a potential systemic allergic reaction. Several studies in adolescents and adults with persistent allergic rhinitis and moderate persistent allergic asthma have shown that SCIT is better tolerated when combined with. Nevertheless, no previous studies have been conducted in children and adolescents with severe asthma to assess the safety and efficacy of a combination treatment of SCIT and omalizumab.

Methods

We report here the observations of six patients, aged 11 to 21 years, with severe persistent asthma controlled by omalizumab as add-on therapy who received SCIT under a cluster protocol during omalizumab treatment and then SCIT maintenance alone after discontinuation of omalizumab.

Results

Although no patients experienced severe exacerbation, one patient had to stop SCIT after one month of treatment because of uncontrolled asthma. For the five remaining patients, asthma control continued to improve during the combined treatment with SCIT and omalizumab (median time duration = 8 months) despite a decrease in maintenance treatment for all of them. SCIT was continued alone for a median time of 25.5 months and was well tolerated. For these patients, asthma was totally controlled and therapeutic levels of maintenance treatment could be further reduced

Conclusion

Pretreatment by omalizumab for patients with persistent severe allergic asthma seems to improve the safety and probably also the efficacy of SCIT. These results open up perspectives of SCIT for children suffering from severe allergic asthma. However,the primary outcomes of these observations are not included in a standardized protocol and will require further confirmation by prospective double blind studies.

Authors’ Affiliations

(1)
Armand Trousseau Children's Hospital, Allergology Department

Copyright

© Lambert et al; licensee BioMed Central Ltd. 2015

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

Advertisement