Volume 4 Supplement 3

6th Drug Hypersensitivity Meeting (DHM 6)

Open Access

Chlorhexidine in cosmetic products a market survey

  • Morten Schjørring Opstrup1,
  • Jeanne Duus Johansen1,
  • Rossana Bossi2,
  • Michael Dyrgaard Lundov1 and
  • Lene Heise Garvey3
Clinical and Translational Allergy20144(Suppl 3):P69

DOI: 10.1186/2045-7022-4-S3-P69

Published: 18 July 2014

Background

Chlorhexidine may cause both type I and type IV allergy, but the mode of sensitization is unknown. It is a widely used disinfectant in the health care setting as well as an ingredient in cosmetic products, but the extent of use is unknown. According to the European Cosmetic Directive, chlorhexidine is allowed in cosmetic products in a concentration of up to 0.3%. The aim of this study was to identify which types of cosmetic products that contain chlorhexidine, and to measure their concentration of chlorhexidine.

Method

The study took place February 2013 April 2013 in Copenhagen, Denmark. All cosmetic products in 14 supermarkets, one hairdresser, one beauty and retail store and one optician were checked for chlorhexidine by reading the ingredient label. All products were photographed and product names noted to avoid duplicates. The products containing chlorhexidine were purchased. Chlorhexidine concentration was measured in ten selected products by high-performance liquid chromatography (HPLC) with ultraviolet (UV)-detector.

Results

Chlorhexidine was found in 82 out of 2310 cosmetic products (3.5%) in the following categories: Conditioners (n=30), hair dyes (n=13), hair treatments (n=10), creams (n=9), face washes (n=4), wet wipes (n=4), hair styling products (n=4), skin tonics (n=3), contact lens fluids (n=2), make up removers (n=2) and mouth washes (n=1). The concentration of chlorhexidine was measured in ten products to 0.03% 1.54%. Two products, both creams, had a concentration above the allowed 0.3% (0.43% and 1.54%, respectively).

Conclusion

In this market survey, chlorhexidine was identified in 82 different cosmetic products (3.5%), predominantly hair products. Two creams had a concentration of chlorhexidine higher than allowed by the European Cosmetic Directive. The extent of use of chlorhexidine in the health care setting as well as the relevance for allergic sensitization should be further explored.

Authors’ Affiliations

(1)
Copenhagen University Hospital Gentofte, National Allergy Research Centre
(2)
Aarhus University, Institut for Bioscience - Arctic Research Centre
(3)
Copenhagen University Hospital Gentofte, Danish Anaesthesia Allergy Centre, Allergy Clinic

Copyright

© Opstrup et al; licensee BioMed Central Ltd. 2014

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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