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Volume 3 Supplement 2

9th Symposium of Experimental Rhinology and Immunology of the Nose (SERIN 2013): Abstracts

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Matrix metalloproteinases, tissue inhibitor of metalloproteinase and transforming growth factor A1 in the remodeling of chronic rhinosinusitis in North China

Clinical and Translational Allergy volume 3, Article number: O10 (2013) Cite this article

Background

To evaluate the expression and roles of matrix metalloproteinases (MMPs), tissue inhibitor of metalloproteinase (TIMP) 1,2,3,4, and transforming growth factor ¦Â1(TGF-¦Â1) in chronic rhinosinusitis without nasal polyps (CRSsNP) and with nasal polyps (CRSwNP) in North China.

Method

100 cases of NP tissue, 25 cases of sinus mucosa of CRSsNP and 25 cases of control were enrolled in the present study. ELISA was used to measure MMP-1,2,3,7,8,9,12,13 and TGF-¦Â1 in homogenization.

Results

MMP-8,9 were the highest among all above MMPs. MMP-8 of NP tissue was much higher than that of CRS and control tissue (P<0.001). MMP-9 of NP tissue was also significantly higher than that of CRSsNP and control tissue (P<0.05). MMP-7 of NP tissue and CRSsNP were much higher than that of control tissue (P<0.001). MMP-2 of CRSsNP tissue was much higher than that of NP and control tissue (P<0.001). TIMP-1,2 were the highest among all the four TIMPs. TIMP-1 of CRSsNP tissue was much higher than that of NP and control tissue (P<0.001 and P<0.05 respectively). TIMP-2 of NP and CRSsNP tissue were much higher than that of control tissue (P<0.01). TIMP-3 of CRSsNP tissue was much higher than that of NP and control tissue (P<0.01 and P<0.05 respectively). There were no significantly difference of TGF-¦Â1 among the three groups.

Conclusion

Different MMPs and TIMPs may play different roles in the remodeling of CRSsNP and CRSwNP.

Author information

Authors and Affiliations

  1. Department of Otorhinolaryngology Head and Neck Surgery of Beijing Tongren Hospital, Beijing Institute, Beijing, China

    XiangDong Wang

  2. Department of Otorhinolaryngology, Beijing Tongren Hospital, Capital Medical University, Beijing, China

    ChengShuo Wang & MingYu Bo

  3. Department of Otorhinolaryngology, Beijing Institute of Otorhinolaryngology, Beijing, China

    Hong Wang, Ying Li & ErZhong Fan

  4. Department of Otorhinolaryngology, Ghent University Hospital, Ghent, Belgium

    Nan Zhang & Claus Bachert

  5. Department of Otorhinolaryngology, Beijing Tongren Hospital, Capital Medical University, Beijing Institute of Otorhinolaryngology, Beijing, China

    Luo Zhang

Authors
  1. XiangDong Wang
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  2. ChengShuo Wang
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  3. MingYu Bo
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  4. Hong Wang
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  5. Ying Li
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  6. ErZhong Fan
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  7. Nan Zhang
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  8. Claus Bachert
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  9. Luo Zhang
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This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Wang, X., Wang, C., Bo, M. et al. Matrix metalloproteinases, tissue inhibitor of metalloproteinase and transforming growth factor A1 in the remodeling of chronic rhinosinusitis in North China. Clin Transl Allergy 3 (Suppl 2), O10 (2013). https://doi.org/10.1186/2045-7022-3-S2-O10

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  • DOI: https://doi.org/10.1186/2045-7022-3-S2-O10

Keywords

Clinical and Translational Allergy

ISSN: 2045-7022

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